Metabolic reprogramming and M2 macrophage depletion define the microenvironment of adenomyosis.

ABSTRACT:

Background

Adenomyosis is a chronic gynecological disorder characterized by the invasion of endometrial tissues into the myometrium of the uterus, with pathophysiology linked to chronic inflammation and metabolic dysregulation. However, the understanding of the molecular mechanisms and underlying pathologies remains limited. This study aims to elucidate the metabolic reprogramming and immune dysregulation within the eutopic endometrium from patients diagnosed with adenomyosis, and identify potential therapeutic targets or diagnostic indicators.

Methods

We analyzed publicly available microarray (GSE78851), bulk RNA-seq (GSE193928) and single-cell RNA-seq (Human Endometrial Cell Atlas) datasets to explore the microenvironment of eutopic endometrium from adenomyosis patients. T

SUBMITTER: Bian X 

PROVIDER: S-EPMC12675163 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature