Ion channels and atrial fibrillation: mitophagy as a key mediator.

ABSTRACT:

Background

The prevalence of atrial fibrillation (AF) is increasing due to the aging population. Mitophagy is crucial for maintaining cardiomyocyte function, while ion channels play a key role in cardiac electrical activity. Dysfunction of ion channels can trigger AF. However, the role of mitophagy-related ion channel genes in AF remains unclear.

Methods

AF-related datasets GSE41177 and GSE79768 were merged and batch-corrected for differential expression analysis. Mitophagy-related and ion channel-related genes were obtained from the MsigDB and GeneCards databases. Immune infiltration and functional enrichment analyses were performed. Sixty-five machine learning models were developed to identify Hub genes, with the optimal model selected based on receiver operating character

SUBMITTER: Wu X 

PROVIDER: S-EPMC12675238 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature