Deciphering the let-7c-5p/RRM2 axis in lung adenocarcinoma: expression, prognosis, and immune landscape implications.

ABSTRACT:

Objective

Lung adenocarcinoma (LUAD) is a subtype of non-small cell lung cancer with a poor prognosis. Ribonucleotide reductase subunit M2 (RRM2) has been implicated in the progression of various cancers, but its role in LUAD remains underexplored. This study aims to elucidate the expression patterns, clinical significance, and regulatory mechanisms of RRM2 in LUAD.

Methods

We conducted a comprehensive analysis of RRM2 expression using data from the Genomic Data Commons Data Portal and The Cancer Genome Atlas. Survival analysis was performed using the KM plotter tool. The starBase database was utilized to identify miRNAs associated with RRM2. Single-cell RNA sequencing data was analyzed to explore the correlation between RRM2 and immune cell infiltration. In vitro exp

SUBMITTER: Liu J 

PROVIDER: S-EPMC12675248 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature