The astrocytic ensemble acts as a multiday trace to stabilize memory.

ABSTRACT: Recalled memories become transiently labile and require stabilization^1-3. The mechanism for stabilizing memories of survival-critical experiences, which are often emotionally salient and repeated, remains unclear⁴. Here we identify an astrocytic ensemble that is transcriptionally primed by emotional experience and functionally triggered by repeated experience to stabilize labile memory. Using a novel brain-wide Fos tagging and imaging method, we found that astrocytic Fos ensembles were preferentially recruited in regions with neuronal engrams⁵ and were more widespread during fear recall than during conditioning. We established the induction mechanism of the astrocytic ensemble, which involves two steps: (1) an initial fear experience that induces day-long,

SUBMITTER: Dewa KI 

PROVIDER: S-EPMC12675280 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature