Population-specific polygenic risk scores for people of Han Chinese ancestry.

ABSTRACT: Predicting complex disease risks on the basis of individual genomic profiles is an advancing field in human genetics^1,2. However, most genetic studies have focused on populations of European ancestry, creating a global imbalance in precision medicine and underscoring the need for genomic research in non-European groups^3,4. The Taiwan Precision Medicine Initiative recruited more than half a million Taiwanese residents, providing a large dataset of genetic profiles and electronic medical record data for people with Han Chinese ancestry. Using extensive phenotypic data, we conducted comprehensive genomic analyses across the medical phenome with individuals genetically similar to Han Chinese reference populations. These analyses identified population-specific genetic risk

SUBMITTER: Chen HH 

PROVIDER: S-EPMC12675292 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature