Quantifying the impact of pre-vaccination titre and vaccination history on influenza vaccine immunogenicity.

ABSTRACT: Epidemiological studies suggest that heterogeneity in influenza vaccine antibody response can be associated with specific host factors, including pre-vaccination immune status, age, gender, and vaccination history. However, the pattern of reported associations varies between studies. To better understand the underlying influences on antibody responses, we combined host factors and vaccine-induced in-host antibody kinetics from a cohort study conducted across multiple seasons with a unified analysis framework. We developed a flexible individual-level Bayesian model to estimate associations and interactions between host factors, including pre-vaccine HAI titre, age, sex, vaccination history and study setting, and vaccine-induced HAI titre antibody boosting and waning. We applied the model to

SUBMITTER: Hodgson D 

PROVIDER: S-EPMC12675300 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature