Reduced ovarian reserve among female offspring of consanguineous marriages in the Middle East-a mini review.

ABSTRACT:

Background

Consanguineous marriages remain prevalent in many regions of the world, particularly within the Middle East, where reported prevalence exceeds 50% in countries such as Saudi Arabia, Oman, and the United Arab Emirates. Despite evidence that consanguineous marriages increase genetic risks through increased levels of homozygosity, which might lead to gene dysfunction, their impact on female fertility remains unclear. Although the data is limited and inconsistent, female offspring of consanguineous marriages appear to have a higher risk of reduced ovarian reserve compared to their peers from non-consanguineous marriages, with a more pronounced effect in young women.

Aim

This mini review synthesizes current evidence on the relationship between parental consanguinity an

SUBMITTER: Bayoumi R 

PROVIDER: S-EPMC12675336 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature