Mortality trends in extremely premature neonates: insights from the CDC WONDER database from 1999 to 2023.

ABSTRACT:

Introduction

Premature birth is associated with significant morbidity and mortality. Risk increases with younger gestational age. The ICD-10-CM code classifies extremely immature neonates as being born at less than 28 weeks gestation. Antenatal and neonatal interventions have improved outcomes overall. This study evaluates trends in extreme prematurity related mortality to determine if outcomes are evenly distributed among demographic groups, including pre and post COVID data.

Methods

The CDC WONDER database was utilized to gather data on extreme immaturity related mortality in infants <1 year old from 1999 to 2023. Joinpoint regression was subsequently utilized for data analysis, analyzing crude mortality rate (CMR), annual percent change (APC), and average annual percent c

SUBMITTER: Hammond R 

PROVIDER: S-EPMC12675377 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature