Associations between gut microbiota and immune status in untreated B-cell lymphoma patients.

ABSTRACT:

Background

Emerging evidence links gut microbiota to tumorigenesis via immune modulation, though subtype-specific microbial signatures in B-cell lymphomas remain unclear. This study explores microbiota-immune interactions across lymphoma subtypes to inform microbiota-targeted therapies.

Methods

Twenty-seven treatment-naive B-cell lymphoma patients (8 DLBCL, 5 SLL, 5 FL, 7 MZL, 2 WM) and 20 HCs were enrolled. Fecal 16S rDNA sequencing, flow cytometry for immune cell subsets, and ELISA for cytokines/immunoglobulins were performed. Microbiota differences and correlations with immune parameters were analyzed.

Results

B-cell lymphoma patients showed lower fecal microbiota richness/evenness (P<0.05), with increased Actinobacteriota, Bacilli, Enterobacteriaceae and de

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12675396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature