Genomic dissection of the antimicrobial resistance epidemiology of <i>Salmonella</i> Typhimurium.

ABSTRACT:

Introduction

Salmonella Typhimurium (STm) is a globally distributed foodborne pathogen showing increasing antimicrobial resistance (AMR), particularly to fluoroquinolones and third-generation cephalosporins. Multiple countries have implemented ongoing genomic surveillance programs for Salmonella, but comprehensive global analyses integrating genomic typing and AMR in STm remain scarce.

Methods

Publicly available genomes of ~65,000 STm isolates were characterized using Multilevel Genome Typing (MGT). Resistance was predicted to 14 clinically-relevant antibiotics. Resistance patterns were analyzed by MGT sequence type (ST), geographic location, year of collection, and source. MGT ST where ≥80% isolates were predicted to be resistant to an antibiotic were defined

SUBMITTER: Kaur S 

PROVIDER: S-EPMC12675436 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature