Global and regional burdens of opioid use disorder from 1990 to 2021, with future forecasts to 2050: a systematic analysis for the global burden of disease study 2021.

ABSTRACT:

Introduction

This study comprehensively investigated the magnitude and temporal trends of the global burden of opioid use disorder (OUD) from 1990 to 2021 and predicted the disease burden in the next 29 years.

Methods

The data originated from the Global Burden of Disease 2021 study. Incidence, prevalence, deaths, and disability-adjusted life years (DALYs) were analyzed by age-standardized rates. The estimated annual percentage change was calculated. The decomposition analysis was used to analyze the changes in burden globally and across the five social demographic index (SDI) regions from 1990 to 2021, with the affected population broken down into three key determinants at the group level: population aging, population growth, and epidemiological changes. Age-period-cohort an

SUBMITTER: Cao J 

PROVIDER: S-EPMC12675459 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature