Development and validation of a nomogram for early prediction of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in children.

ABSTRACT:

Background

Mycoplasma pneumoniae (MP) is a leading cause of community-acquired pneumonia in children, with a significant increase in incidence following the COVID-19 pandemic. The emergence of macrolide-resistant M. pneumoniae (MRMP) has complicated treatment, leading to the concept of macrolide-unresponsive M. pneumoniae pneumonia (MUMPP), defined as lack of improvement after 72 h of macrolide therapy. Early identification of MUMPP is critical for timely intervention and improved outcomes. This study aimed to develop and validate a nomogram for early prediction of MUMPP in children.

Methods

We conducted a retrospective study involving 278 pediatric patients with MP pneumonia, divided into training (n = 188) and validation (n = 90) sets. Demographic, clinical,

SUBMITTER: Liu H 

PROVIDER: S-EPMC12675469 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature