Si-Miao-Yong-An decoction suppresses necroptosis by regulating the p53 pathway in myocardial ischemia/reperfusion injury.

ABSTRACT: Myocardial ischemia/reperfusion (I/R) injury is a serious complication during the recanalization treatment of myocardial infarction (MI), which seriously affects the prognosis of patients. As a renowned traditional Chinese medicinal formulation, Si-Miao-Yong-An decoction (SMYA) has therapeutic effects on myocardial I/R injury, although its underlying mechanisms, particularly concerning regulated cell death pathways, are not fully understood. This study aimed to explore the therapeutic effect and possible mechanism of SMYA in myocardial I/R injury. C57BL/6J mice were divided into sham, model, and SMYA-treated groups (low, medium and high-dose). In this study, we identified 13 main components of SMYA using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UH

SUBMITTER: Li X 

PROVIDER: S-EPMC12675494 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature