Mechanisms of Okanin against wound healing based on network pharmacology, molecular docking and molecular dynamics simulation.

ABSTRACT: Wound healing is a critical aspect of modern medicine, impacting patient health, quality of life, and healthcare resource allocation. Okanin, a flavonoid from the Asteraceae family, has shown potential in promoting wound healing. This study investigates okanin's key molecular targets, binding affinity, and mechanisms of action using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experimental validation. Okanin's potential targets were identified using the Comparative Toxicogenomics Database (CTD) and SwissTargetPrediction, while wound healing-related targets were sourced from GeneCards and DrugBank. Overlap analysis of these datasets revealed common targets. Key target proteins were filtered through protein-protein interaction (PPI) analysis using the

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12675513 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature