Doxycycline safety during pregnancy: a large population-based cohort of pregnancies.

ABSTRACT:

Purpose

Doxycycline is frequently prescribed during pregnancy, yet evidence on fetal safety is inconsistent and often excludes non-live births. We assessed whether exposure during the first or third trimester is associated with major congenital malformations or late-pregnancy adverse outcomes in a population-based cohort that also included stillbirths and terminations.

Methods

Using data from Clalit Health Services Southern district, we identified 265,686 pregnancies in women aged 15-45 years (from 1998 to 2017). Pharmacy records classified doxycycline dispensation in the first trimester (≤ 13 weeks) or third trimester (≥ 27 weeks). Crude and adjusted negative-binomial models estimated relative risks (RRs) for total and organ-specific major congenital malformations diagnosed

SUBMITTER: Shitrit IB 

PROVIDER: S-EPMC12675617 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature