Unveiling hidden neurodegeneration in isolated REM sleep behavior disorder through MRI microstructure and glymphatic flow.

ABSTRACT: This study aimed at: (1) assessing microstructural MRI and glymphatic flow alterations in isolated REM sleep behavioral disorder (iRBD) subjects relative to controls; (2) comparing sub-groups of iRBD patients with different levels of disease severity; and (3) studying the correlations between clinical alterations and MRI changes. 44 iRBD subjects and 52 controls underwent clinical and MRI evaluations. Gray and white-matter microstructural alterations were studied. Diffusion-tensor image analysis along the perivascular space (DTI-ALPS) index was obtained for the evaluation of glymphatic flow functionality. Cluster analysis was applied to divide iRBD patients in sub-groups. IRBD subjects showed worse sleep quality, reduced manual dexterity and gait alterations relative to controls. IRBD had

SUBMITTER: Basaia S 

PROVIDER: S-EPMC12675625 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature