Olefin metathesis of phospholipids by Ruthenium-based catalysts in solution and on liposomes under biologically relevant conditions.

ABSTRACT: The last decade has seen a lot of interest in classical organometallic catalysis performed intracellularly, or at least under biological conditions (37 °C, air, water). One such classical reaction is olefin metathesis (OM), which is extremely common in preparative organic chemistry, however under non-biological conditions (esp. organic solvents). For in vivo applications, both prokaryotic and eukaryotic applications would require the passage of the OM catalyst through the cell membrane, which already contains unsaturated olefins and thus potential substrates for OM. This work focuses on the question whether OM is catalysed in membranes containing unsaturated phospholipids. Initial experiments with the 2nd generation Hoveyda-Grubbs catalyst (HGII) showed self-metathesis of the membrane-form

SUBMITTER: Eichert P 

PROVIDER: S-EPMC12675672 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature