SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels.

ABSTRACT: Pediatric diffuse high-grade gliomas (pHGGs) are heterogeneous and infiltrative tumors with poor prognosis. Recent molecular characterization of pHGGs has revealed an altered epigenetic profile with aberrant post-translational modifications and increased histone 3 lysine 9 trimethylation (H3K9) to be implicated in their pathology. Herein, we investigate the expression and biological role of the methyltransferase suppressor of variegation 3-9 homolog 1 (SUV39H1) in regulating key cancer hallmarks, including cell proliferation, motility, and epithelial-mesenchymal transition (EMT) gene regulation of pHGG. Bioinformatic analysis of SUV39H1 mRNA levels was performed in a public database of pediatric gliomas with respective controls. SUV39H1 protein expression was further investigated in a coho

SUBMITTER: Klonou A 

PROVIDER: S-EPMC12675686 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature