Irisin-induced cardiac fibroblast proliferation is dependent on glucose concentration and is inhibited by WZB117.

ABSTRACT:

Backgrounds

Fibroblast proliferation is influenced by inter alia the cellular transport of glucose and its metabolism. The aim of the study is to confirm whether irisin is involved in the regulation of human cardiac fibroblast proliferation, and whether its effect is dependent on glucose concentration or glucose transporter activity (GLUT1). The study also examines the expression of glucose transporters on the cardiac fibroblast cell membrane.

Methods and results

Human cardiac fibroblasts were cultured under hypoglycemia (1 mmol/l), normoglycemia (5 mmol/l) or hyperglycemia (25 mmol/l), and treated with different concentrations of irisin (10^- 7 M, 10^- 8 M and 10^- 9 M). The results indicate that glucose concentration had no influence on cardia

SUBMITTER: Drobnik M 

PROVIDER: S-EPMC12675697 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature