Neuroanatomical characterization of the cell adhesion molecule IgSF9b reveals localization to inhibitory and excitatory synapses in the mouse limbic system.

ABSTRACT: Immunoglobulin superfamily member 9b (IgSF9b) is a cell adhesion protein that has been linked to the etiology of several neuropsychiatric disorders, most notably schizophrenia and major depression. Based on previous studies in cultures, IgSF9b was proposed to specifically regulate the structure and function of inhibitory synapses in the brain through an indirect interaction with the synaptic adhesion protein Neuroligin-2 (Nlgn2). However, very little is known about the protein expression pattern of IgSF9b in the intact brain, and the synaptic localization of IgSF9b in different brain regions has never been investigated. To address this question, we conducted an immunohistochemical characterization of IgSF9b expression across the mouse brain and investigated its colocalization with gephyrin

SUBMITTER: Rotondo F 

PROVIDER: S-EPMC12675716 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature