Endothelin-1 in combination with CRB-65 enhance risk stratification in COVID-19 patients.

ABSTRACT:

Background

COVID-19 continuously causes severe disease conditions and significant mortality. We evaluate whether easily accessible biomarkers can improve risk prediction of severe disease outcomes.

Methods

Our study analysed 426 COVID-19 patients collected by German CAPNETZ and PROGRESS study groups between 2020 and 2021. Troponin T high-sensitive (TnT-hs), procalcitonin (PCT), N-terminal pro brain natriuretic peptide, angiopoietin-2, copeptin, endothelin-1 (ET-1) and lipocalin-2 were measured at enrolment and related to 28d mortality/ICU admission endpoint. Logistic and relaxed LASSO regression were used to evaluate the added value of biomarkers compared to the CRB-65 score and to develop a combined risk prediction model for our endpoint.

Results

Of the 426 COVID-19

SUBMITTER: Farhat I 

PROVIDER: S-EPMC12675736 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature