Performance of whole blood interferon-γ release assays in SARS-CoV-2 and tuberculosis is age dependent.

ABSTRACT:

Introduction

A lot of research has been done, mainly on tuberculosis (TB), on the extent to which cellular immune protection as measured by interferon-γ release assays (IGRA) is age-dependent. In a previous study we showed that following an Omicron infection, adolescents with a hybrid immunity had a higher probability of having a reactive SARS-CoV-2-specific IGRA than children. Therefore, we examined in a large group of minors and adults whether age influences cellular immunity as measured by IGRA in TB and SARS-CoV-2.

Methods

Participants were recruited at 13 German study sites between September and December 2022. Cellular immunity was analyzed using SARS-CoV-2 and Tb-specific IGRA and humoral immunity against SARS-CoV-2 by measuring antibodies against spike (S) and nucleoc

SUBMITTER: Rothoeft T 

PROVIDER: S-EPMC12675746 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature