Propolis impairs cellular proliferation by promoting oxidative damage and disrupting macromolecular composition in a yeast model.

ABSTRACT: Propolis, a bee-derived resin with diverse pharmacological properties has an unclear dose-dependent effect on cellular homeostasis. This study evaluated the toxicological effects of a standardized 10% (w/v) water-soluble extract of Anatolian propolis on the eukaryotic model organism Saccharomyces cerevisiae. Wild-type yeast and its isogenic deletion mutants lacking cytosolic catalase T, thioredoxin-disulfide reductase, and glutathione synthase were exposed to propolis at 0.005-0.125% (v/v) for 24 h. Cell proliferation assays demonstrated that propolis was nontoxic to wild-type cells up to 0.01% (v/v) but significantly reduced proliferation at ≥ 0.025% (v/v). Furthermore, 0.01% (v/v) propolis notably impaired cell proliferation in mutant strains relative to the wild type. FTIR spectroscopy

SUBMITTER: Yardımcı BK 

PROVIDER: S-EPMC12675780 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature