Histone post-translational modifications of Leishmania braziliensis.

ABSTRACT: Histone post-translational modifications (hPTMs) constitute an epigenetic mechanism that plays a fundamental role in the regulation of gene expression in eukaryotic cells. In trypanosomatid parasites, such as Trypanosoma brucei, T. cruzi and Leishmania spp., gene regulation occurs mainly at the post-transcriptional level. Nevertheless, recent studies have demonstrated that hPTMs are abundant and diverse in T. brucei and T. cruzi, the causative agents of sleeping sickness and Chagas disease, respectively, suggesting a potential regulatory role for histone modifications in these organisms. However, data on hPTMs in Leishmania parasites, the etiological agents of leishmaniasis, remain scarce. Here, applying an optimized mass spectrometry-based proteomic workflow, we present the first large-sc

SUBMITTER: de Almeida RF 

PROVIDER: S-EPMC12675788 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature