A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche.

ABSTRACT: The interaction between hematopoietic stem and progenitor cell (HSPC) and its vascular niche is essential for supporting the homeostasis and reconstitution of hematopoietic system in adult bone marrow (BM), but a comprehensive atlas covering this HSPC-vascular niche crosstalk in multiple developmental stages and species is lacking. Here, we integrated single-cell transcriptomic data of HSPC and its vascular niches from fetal liver until aged BM, covering two species, two organs, and six developmental time points. Comparative analyses revealed dramatic differences in the gene expression, enriched pathway, and cell-cell communication between human fetal and adult BM. Notably, many of these differences were conserved between humans and mice. Multi-timepoint profiling of murine BM vascular nic

SUBMITTER: Ma LY 

PROVIDER: S-EPMC12675905 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature