Targeting IL6-Edn1-FoxO1 axis enables lung growth in mechanically ventilated newborn mice.

ABSTRACT:

Rationale

Mechanical ventilation is a life-saving treatment for preterm infants that often leads to bronchopulmonary dysplasia (BPD). We previously demonstrated a reduced number of alveolar epithelial cells with a depletion of alveolar epithelial type 2 cells (AT2) in lungs of infants with BPD.

Objective

To investigate and target the mechanisms by which mechanical ventilation causes an arrest of alveolarisation.

Methods

Experimental mouse model of neonatal ventilation-induced lung injury (VILI) in wild-type mice, Il6-null mice, and pharmacological inhibition of interleukin (IL)-6 and endothelin receptors. Complementary, precision-cut lung slices (PCLS) and primary cells were analysed. Moreover, lungs of infants with BPD were studied.

Results

Mechanical v

SUBMITTER: Hirani D 

PROVIDER: S-EPMC12675960 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature