Bivalent Histone Modifications Orchestrate Temporal Regulation of Glucosinolate Biosynthesis During Wound-Induced Stress Responses in Arabidopsis.

ABSTRACT: Glucosinolates (GSLs) are secondary metabolites central to plant defence in the Brassicaceae family. While the role of histone modifications in developmental gene regulation is well studied, their function in stress-induced secondary metabolism remains unclear. Here, we show that GSL biosynthetic genes in Arabidopsis thaliana are regulated by bivalent chromatin bearing both active (histone acetylation) and repressive (H3K27me3) histone marks. Components of the Polycomb Repressive Complex 2 (PRC2), including CLF, SWN and LHP1, suppress GSL gene expression, and their loss enhances GSL accumulation. Genome-wide analyses revealed that indolic and aliphatic GSL genes are enriched with H3K27me3, with indolic genes also marked by active histone acetylation. Time-course transcriptome and metabolit

SUBMITTER: Choi D 

PROVIDER: S-EPMC12675981 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature