Mild photothermal-mediated neuroimmunomodulatory composite hydrogel ameliorates bone healing microenvironment for enhanced osteoporotic bone defect regeneration.

ABSTRACT: The treatment of osteoporotic bone defects represents a substantial clinical challenge in contemporary orthopedics due to the abnormal accumulation of reactive oxygen species (ROS) and elevated inflammatory levels. Despite advances in bone graft materials for enhancing bone regeneration, developing an ideal therapeutic strategy capable of orchestrating the multidimensional biological processes underlying bone healing, such as immunomodulation, angiogenesis, osteogenesis and innervation, remains a formidable challenge in orthopedic biomaterial design. In our study, a multifunctional composite hydrogel (Ce@Mo/GC) was developed through the incorporation of CeO₂@Mo₂Ti₂C₃ MXene (Ce@Mo) heterojunction structures into gelatin methacryloyl (GelMA)/carbox

SUBMITTER: Song Q 

PROVIDER: S-EPMC12676112 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature