Renal thrombotic microangiopathy impairs renal function recovery in lupus nephritis.

ABSTRACT:

Background

Renal thrombotic microangiopathy (TMA) remains a challenge for lupus nephritis (LN) patients. The purpose of this study was to determine the prognostic significance of renal TMA in patients with LN.

Methods

Patients were recruited from the LN database (http://ln.medidata.cn) of the First Affiliated Hospital of Sun Yat-Sen University between 2001 and 2023. To assess the association between renal TMA and kidney recovery outcomes, propensity score matching (PSM), and Cox proportional hazards regression analysis were used.

Results

5.17% LN patients had kidney biopsies showing TMA. After PSM, patients with renal TMA exhibited lower scores on the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the Activity Index (AI) scores in renal biopsies. Ren

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12676121 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature