The Effectiveness of Oxytocin for Preventing Postpartum Haemorrhage: An Individual Participant Data Meta-Analysis.

ABSTRACT:

Background

Post-partum haemorrhage (PPH) is a common complication of labour.

Objective

To assess the effectiveness of oxytocin in comparison to no treatment for preventing PPH.

Selection criteria

Published and unpublished randomised controlled trials (RCTs) comparing systemic oxytocin to placebo or no intervention for preventing PPH were included. We did not apply language restrictions.

Search strategy

We identified RCTs from the Cochrane network meta-analysis on uterotonics for preventing PPH and updated the search via: Ovid MEDLINE, Embase via Ovid, Web of Science, CENTRAL, CINAHL Plus and clinicaltrials.gov.

Data collection and analysis

An Individual participant data (IPD) meta-analysis.

Main results

Of 14 eligible RCTs, four provided IPD (n = 

SUBMITTER: Flanagan M 

PROVIDER: S-EPMC12676194 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature