New Se-Compounds With Antileishmanial, Antitumor, and Carbonic Anhydrase Inhibitory Properties.

ABSTRACT: In the pursuit of novel agents for treating leishmaniasis and cancer, we have synthesized a small library of phenylcarboxamide-selenium analogs and evaluated their in vitro antileishmanial, anticancer, and carbonic anhydrase inhibitory activities. The two trifluoromethoxy-substituted aniline derivatives (3 and 6) exhibited IC₅₀ values in the low micromolar range in both Leishmania major and Leishmania infantum promastigotes and presented better selectivity indexes (SIs) than the reference drugs (miltefosine and paromomycin). Furthermore, all of the reported compounds displayed an outstanding antitumoral activity against a panel of 60 cancer cell lines of the National Cancer Institute's (NCI) Developmental Therapeutic Program (DTP). The cytotoxicity of compounds 1-3 in nonmaligna

SUBMITTER: Moran-Serradilla C 

PROVIDER: S-EPMC12676205 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature