Health Trajectories around Noninvasive Ventilation Initiation for Obesity Hypoventilation Syndrome.

ABSTRACT: Rationale: Positive airway pressure therapy modalities in obesity hypoventilation syndrome (OHS) are still debated. Objectives: To describe health trajectories before and after starting noninvasive ventilation (NIV) and compare post-NIV outcomes between groups with different pre-NIV trajectories. Methods: Data came from the French national health insurance reimbursement database for individuals with OHS and one or more NIV prescriptions between January 1, 2015, and December 31, 2019. Health trajectory clusters were determined using mixture models that were graphically represented by time sequence analysis. Results: Data from 8,842 individuals were analyzed (59.7% had coexisting obstructive sleep apnea, 64% had one or more comorbidities). Median follow-up was 3.1

SUBMITTER: Pepin JL 

PROVIDER: S-EPMC12676264 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature