Identification and validation of mitochondrial and programmed cell death-related prognostic markers in pediatric acute myeloid leukemia.

ABSTRACT:

Background

Pediatric acute myeloid leukemia (AML) is characterized by poor prognosis and low survival rates following recurrence. While mitochondria and programmed cell death (PCD) are implicated in various diseases, their role in pediatric AML remains poorly understood. Identifying prognostic genes associated with PCD and mitochondrial function could enhance therapeutic approaches.

Methods

Transcriptomic data and gene sets were sourced from public databases. Differentially expressed genes (DEGs) that intersected with PCD-related genes (PCD-RGs) and mitochondrial-related genes (mito-RGs) were selected as candidate genes. Regression analyses were performed to identify prognostic genes, which were then used to develop and validate a prognostic model. A nomogram was constructed

SUBMITTER: Hu X 

PROVIDER: S-EPMC12676267 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature