Transport of Molecular Iodine From Antiseptic Iodophors across Hydrophilic-lipophilic Interfaces: Influence of Phospholipids.

ABSTRACT: The release and transport of molecular iodine (I₂) from antiseptic iodophors across hydrophilic-lipophilic interfaces were studied to understand the impact of carrier polymers and phospholipids on release and transport of molecular iodine across biologically relevant interfaces. Five commercial povidone-iodine formulations and one modified dextrin-iodine complex, each standardized to 1% thiosulfate titratable iodine, were tested using a heptane-water interface model. Iodine release was quantified by both UV-vis spectroscopy and thiosulfate titration with and without phospholipid-rich lipophilic phase. Dilution significantly increased I₂ release, with dextrin-iodine achieving near-complete transfer at higher dilutions due to reduced polymer-iodine binding. Phospholipid

SUBMITTER: Engert M 

PROVIDER: S-EPMC12676293 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature