How Does the Replacement of Acetate Arms with Acetamide Ones in the Structure of Chelators Affect Complexation with Pb^2<b>+</b> ?

ABSTRACT: The growing interest in the application of Pb²⁺ complexes in fields such as radiopharmaceuticals encourages a more thorough study of the coordination chemistry of this metal ion and the search for a desirable chelating agent. In this work, a comparative study of the complexing properties of various acetate and acetamide chelators was carried out to determine which pendant arms are preferable for binding the Pb²⁺ ion. The study focused on chelators containing the same pyridine bisamide fragment in their structure, while the type of chelator, the size of the macrocyclic cavity, and the number of pendant arms were varied. To better understand the impact of specific factors on Pb²⁺ binding, the discussion was supplemented with literature data on the complexatio

SUBMITTER: Zubenko AD 

PROVIDER: S-EPMC12676294 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature