Identification of Neurotrophic Factor Related Biomarkers and Mechanistic Insights into Neuropathic Pain via Integrated Bioinformatics Analysis.

ABSTRACT: Neurotrophic factors are closely associated with the development of neuropathic pain (NPP), yet their underlying mechanisms remain unclear. This study aims to identify key biomarkers and explore their potential mechanisms using integrated bioinformatics approaches. The data sets of NPP were retrieved from public databases. Single-cell RNA sequencing analysis of mouse dorsal root ganglion (DRG) was executed to identify and annotate cell clusters. Differential expression analyses, Friend analysis, and expression validation were executed to screen biomarkers. Gene-gene interaction (GGI) network construction and enrichment analyses were used to explore the relevant functions of the biomarkers. Immune microenvironment differences between case and control were assessed by single sample gene set

SUBMITTER: Liu J 

PROVIDER: S-EPMC12676309 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature