Dissecting Genetic and Environmental Determinants of Plasma Molecular Signatures and Their Link to Type 2 Diabetes Risk.

ABSTRACT:

Background

Type 2 diabetes (T2D) is a heterogeneous disease shaped by both genetic, environmental, cultural, and socioeconomic factors, with well-documented disparities in incidence across populations. The molecular pathways underlying these disparities, however, remain poorly understood. Plasma metabolites and proteins integrate both genetic and environmental influences on type 2 diabetes (T2D) risk, providing insight into disease mechanisms. We aimed to quantify the variance in these molecular profiles explained by environmental and genetic ancestry domains and to apply causal inference approaches to identify environmentally and genetic ancestry influenced pathways contributing to T2D risk.

Methods

We analyzed plasma proteomic and metabolomic profiles from 3,360 MESA parti

SUBMITTER: Sevilla-Gonzalez M 

PROVIDER: S-EPMC12676399 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature