Youth Correlates of Genetic Liability to Substance Use Disorders.

ABSTRACT: Substance use disorders (SUDs) are moderately-highly heritable and develop in stages that typically begin in adolescence/young adulthood. It remains unclear whether SUD correlates reflect predispositional risk and/or arise as consequences of exposure. Our phenome-wide association study (PheWAS) of polygenic risk for SUDs (i.e., Problematic Alcohol Use [PAU], Tobacco Use Disorder [TUD], Cannabis Use Disorder [CUD], Opioid Use Disorder [OUD], and General Addiction Risk Factor [ADDrf]) in 1,584-5,556 8-13-year-old children enrolled in the Adolescent Brain Cognitive Development (ABCD) Study identified 309 phenotypic associations, particularly among mental health, sleep, screen time, and caffeine consumption phenotypes. Most associations were observed in substance naïve participants. Neuroimagi

SUBMITTER: Paul SE 

PROVIDER: S-EPMC12676401 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature