Shared Genetic Architecture and Neurobiological Pathways of Problematic Alcohol Use and Anxiety Disorders.

ABSTRACT:

Background

Problematic alcohol use (PAU) and anxiety disorders (ANX) frequently co-occur, implying shared genetic and neurobiological foundations. However, the directionality of potential causal relationships and the specific mechanisms underlying the overlap remain unclear. Thus, we investigated the shared genetic architecture and neurobiological pathways between PAU and ANX using a multimethod genomic approach.

Methods

We analyzed summary statistics from genome-wide association studies (GWAS) of PAU and ANX using Mendelian randomization to assess causal associations between ANX and PAU. We used MiXeR to assess the overall shared genomic architecture, Local Analysis of (co)Variant Association to estimate regional genetic correlations, and conjunctional false discovery rate

SUBMITTER: Shi M 

PROVIDER: S-EPMC12676416 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature