Protein kinase CK2α' as a dual modulator of immune signaling and synaptic dysfunction in Tauopathy.

ABSTRACT: Tauopathies are a group of neurodegenerative diseases characterized by tau accumulation, neuroinflammation, and synaptic dysfunction, yet effective treatments remain elusive. Protein Kinase CK2 has been previously associated with different aspects of tau pathology but genetic evidence for the contribution of CK2 to tauopathy remained lacking. Here, we show CK2α', one of the two catalytic subunits of CK2, as a novel regulator of tau-mediated neurodegeneration. We found that CK2α' expression is elevated in postmortem brains of dementia patients and in the hippocampus of PS19 tauopathy mice, especially in neurons and microglia. Using genetic haploinsufficiency in PS19 mice, we demonstrated that reduced CK2α' levels significantly decrease phosphorylated tau and total tau burden in the hippocam

SUBMITTER: White A 

PROVIDER: S-EPMC12676539 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature