Associations of children's urinary metals with blood RNA N⁶-methyladenosine and 2'-O-methyladenosine.

ABSTRACT:

Background

Post-transcriptional RNA modifications (the epitranscriptome) regulate gene expression and represent a pathway through which environmental exposures can affect health. Two RNA modifications important for health and disease are N⁶-methyladenosine (m⁶A) and 2'-O-methyladenosine (Am). However, the effects of metals and metalloids (hence, metals), on m⁶A and Am are less well understood. We aimed to investigate associations between children's metals exposures and global m⁶A and Am in blood.

Methods

We measured essential (cobalt, copper, selenium, zinc) and nonessential (arsenic, cadmium, chromium, cesium, mercury, antimony) metals in urine and total m⁶A and Am in blood using liquid chromatography-tandem mass spectr

SUBMITTER: Gigot C 

PROVIDER: S-EPMC12676561 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature