Traumatic brain injury and mortality in older adults with and without pre-injury dementia.

ABSTRACT:

Background

Incidence of traumatic brain injury (TBI) is rising in older adults. Dementia is a common comorbidity and may worsen post-TBI outcomes, but its effects have not been studied.

Objective

To compare all-cause mortality following TBI or non-TBI trauma (NTT) and quantify the impacts of age, deprivation and dementia.

Design

Population-based retrospective cohort study.

Setting

Linked primary and secondary care electronic health records from the Secure Anonymised Information Linkage Databank.

Subjects

Adult residents in Wales aged 18-100 with hospitalised TBI or NTT recorded between January 2000 and December 2022.

Methods

Cox proportional hazard models were used to estimate survival within 1, 6 and 12 months of hospitalised TBI/NTT in those wit

SUBMITTER: Lai H 

PROVIDER: S-EPMC12676572 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature