IgM, IgG, and IgG Subclass Antibody Responses to Plasmodium falciparum Proteins in Naive, Malaria-Vaccinated and Semi-Immune Volunteers after Controlled Human Malaria Infection.

ABSTRACT: The immune response to malaria vaccines is generally stronger in malaria-naive individuals than in those with lifelong exposure. The immunological basis for this is unclear. IgM, total IgG, and IgG subclass (IgG1, IgG2, IgG3, and IgG4) antibody responses against 21 pre-erythrocytic and erythrocytic Plasmodium falciparum proteins before and after controlled human malaria infection (CHMI) via the direct venous inoculation of 3,200 P. falciparum sporozoites (PfSPZ) were compared in three groups of volunteers: 1) malaria-naïve (n = 22); 2) malaria-naïve immunized with a PfSPZ chemoattenuated vaccine (PfSPZ-CVac) (n = 27); and 3) lifelong malaria-exposed individuals from Africa (n = 20), including those with normal hemoglobin (n = 11) or sickle cell trait (n = 9). Before and after CHMI, PfSPZ-C

SUBMITTER: Gomez-Perez GP 

PROVIDER: S-EPMC12676597 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature