Olfactory Impairment and Incident Cognitive Decline: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Olfactory impairment (OI) is associated with poor ageing outcomes. While cross-sectional studies found a high prevalence of OI among patients with neurodegenerative diseases, the temporal relationship remains unclear. This meta-analysis aims to synthesise the longitudinal association of OI with cognitive decline (CD).

Methods

PubMed, Embase and Web of Science were searched through August 9, 2024 for longitudinal studies reporting on self-reported and objectively measured OI in adults, in association with CD, measured using validated methods. The outcome of interest was incident CD. Independent authors extracted data, assessed for bias and graded the strength of evidence. A mixed-effects meta-analysis with subgroup, sensitivity and bias analyses was conducted. The

SUBMITTER: Yeo BSY 

PROVIDER: S-EPMC12676659 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature