Clinical impacts of botulinum toxin type A injections for provoked vestibulodynia: insights from randomized controlled trials.

ABSTRACT:

Background

Provoked vestibulodynia (PVD) is a chronic vulvar pain condition often associated with pelvic floor muscle hypertonicity. Botulinum neurotoxin type A (BoNT-A), a neuromuscular transmission blocker, has been proposed as a potential treatment to alleviate PVD-related symptoms. However, its clinical efficacy and safety remain uncertain.

Objective

To systematically assess the efficacy and safety of BoNT-A injections in women with PVD through a meta-analysis of randomized controlled trials (RCTs).

Methods

We conducted a systematic review and meta-analysis following PRISMA guidelines. A comprehensive search of MEDLINE, Embase, and Cochrane Library databases was performed up to March 2025 to identify RCTs comparing BoNT-A injections with placebo. Pooled effect siz

SUBMITTER: Gao Z 

PROVIDER: S-EPMC12676762 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature