Prioritizing acquired risk factors of atherosclerotic cardiovascular disease according to genetic predisposition: implications for precise prevention.

ABSTRACT:

Background

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide. This study aimed to investigate the contributions of acquired risk factors to ASCVD across different genetic risk groups.

Methods

This study included 430,191 participants aged 40 - 69 from the UK Biobank cohort. Population-attributable fractions (PAFs) of 25 acquired risk factors (including four socioeconomic determinants, three psychosocial factors, five lifestyles, nine cardiometabolic factors, and four clinical comorbidities) for coronary artery disease (CAD), ischemic stroke (IS), and peripheral artery disease (PAD) were assessed across three genetic risk groups (low, moderate, and high). The contributions of 25 risk factors to ASCVD were ranked by PAFs within each gen

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12676810 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature