3D bioprinted microneedle patches loaded with gambogic acid-iron-doxorubicin nanozymes for postoperative glioma in situ therapy via ferroptosis synergistic chemosensitization.

ABSTRACT:

Background

Postoperative chemotherapy is essential for glioma treatment but faces two major limitations: the blood-brain barrier (BBB) restricts drug delivery, and tumor chemoresistance reduces therapeutic efficacy. To circumvent these hurdles, we engineered a 3D-bioprinted, sustained-release microneedle patches (MNs@GFD) that can be affixed directly to the postoperative tumor cavity, thereby bypassing the BBB and providing localized, long-term drug delivery. The patch incorporates gambogic acid-iron-doxorubicin nanozymes (GAFe@DOX, GFD) that simultaneously remodel the hypoxic tumor microenvironment via multi-enzyme activity and prime tumor cells for doxorubicin (DOX) cytotoxicity through ferroptosis.

Results

Comprehensive characterization confirmed successful construction o

SUBMITTER: Liu M 

PROVIDER: S-EPMC12676811 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature