Multidimensional structural-functional coupling uncovers network dysregulation and predicts binge-eating severity in bulimia nervosa.

ABSTRACT:

Background

Bulimia nervosa (BN) is a severe psychiatric disorder characterized by dysregulated eating behaviors and impaired cognitive-emotional control. Despite increasing recognition of brain network dysfunction in BN, the interplay between structural connectivity (SC) and functional connectivity (FC), termed SC-FC coupling, remains poorly understood. This study aimed to comprehensively characterize SC-FC coupling alterations in BN using multimodal neuroimaging and to evaluate the predictive value for disordered eating behaviors.

Methods

This study enrolled 79 patients with BN and 69 healthy controls who underwent high-resolution structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and resting-state functional MRI (rs-fMRI). Functional and structura

SUBMITTER: Yu F 

PROVIDER: S-EPMC12676818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature