Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway.

ABSTRACT: Oxidative stress and macrophage migration contribute to chronic inflammation and resultant tissue damage. The nuclear factor erythroid 2‑related factor 2 (Nrf2) antioxidant pathway plays a key role in maintaining redox balance and modulating immune cell behavior. Lipoteichoic acid (LTA), a component of Gram‑positive bacterial membranes, activates macrophages and overproduces reactive oxygen species (ROS), causing oxidative stress and aberrant macrophage migration. In the present study, the effects of glabridin (GBD), a flavonoid from licorice with antioxidant potential, on LTA‑mediated oxidative stress and alveolar macrophage migration were investigated. GBD pretreatment reduced intracellular ROS levels, as measured through 2',7'‑dichlorofluorescin diacetate and dihydroethidium staining. I

SUBMITTER: Hsia CH 

PROVIDER: S-EPMC12676937 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature