CSF proteomic profiles related to cognitive decline in MCI A+ depend on tau levels.

ABSTRACT: Individuals with mild cognitive impairment (MCI) and an abnormal amyloid biomarker (A+) are at considerable increased risk of developing dementia. Still, these individuals vary greatly in rates of cognitive decline, and the mechanisms underlying this heterogeneity remain largely unclear. One factor related to an increased risk of progression to dementia is having an abnormal tau status (T+), but this still explains only part of the variance. Furthermore, previous work has indicated that MCI A+ individuals with T- or T+ are characterized by distinct molecular processes as reflected by distinct CSF proteomic profiles. As such, it could be hypothesized that differences in rates of cognitive decline in A+ MCI with abnormal or normal tau status may be explained by distinct underlying mechanisms

SUBMITTER: Vromen EM 

PROVIDER: S-EPMC12677021 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature